My vote for "Best Screen Capture & Caption of 2005"
I laughed my ass off over this when I first saw it a couple of weeks ago. It comes from a review of The Gingerdead Manover at Cold Fusion Video Reviews. Knowing the context helps understand it, but I still think it's damn funny on it's own:
"'Whaaat a friend we have in Jeeesuus...' Everybody sing!"